InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTG1

Summary

InnateDB Protein

IDBP-93801.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTG1

Protein Name

Mitochondrial GTPase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323047

InnateDB Gene

IDBG-93799 (MTG1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. {ECO:0000269PubMed:23396448}.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0042254	ribosome biogenesis
GO:0044065	regulation of respiratory system process
GO:0070129	regulation of mitochondrial translation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005761	mitochondrial ribosome

Protein Structure and Domains

PDB ID

InterPro

IPR006073 GTP binding domain
IPR016478 GTPase, MTG1
IPR019991 GTP-binding protein, ribosome biogenesis, YlqF
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926

PRINTS

PR00326

PIRSF

PIRSF006230

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt