InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR1D

Summary

InnateDB Protein

IDBP-93836.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR1D

Protein Name

5-hydroxytryptamine (serotonin) receptor 1D

Synonyms

5-HT1D; HT1DA; HTR1DA; HTRL; RDC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000363748

InnateDB Gene

IDBG-93832 (HTR1D)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1565658, ECO:0000269PubMed:1652050}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1565658, ECO:0000269PubMed:1652050}; Multi- pass membrane protein {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1565658, ECO:0000269PubMed:1652050}.

Disease Associations

Tissue Specificity

Detected in brain neocortex and caudate nucleus (at protein level). {ECO:0000269PubMed:1828434}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0051378	serotonin binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0009636	response to toxic substance
GO:0014827	intestine smooth muscle contraction
GO:0040012	regulation of locomotion
GO:0042310	vasoconstriction
GO:0050795	regulation of behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000505 5-Hydroxytryptamine 1D receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00514
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28221