InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MRAP2

Summary

InnateDB Protein

IDBP-93940.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRAP2

Protein Name

melanocortin 2 receptor accessory protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257776

InnateDB Gene

IDBG-93938 (MRAP2)

Protein Structure

UniProt Annotation

Function

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269PubMed:19329486, ECO:0000269PubMed:20371771}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19329486}; Single-pass membrane protein {ECO:0000269PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269PubMed:19329486}; Single-pass membrane protein {ECO:0000269PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269PubMed:20371771}.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:23869016}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in the adrenal gland and brain. Not expressed in other tissues. {ECO:0000269PubMed:19329486}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031780	corticotropin hormone receptor binding
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0031783	type 5 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007631	feeding behavior
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0034394	protein localization to cell surface
GO:0097009	energy homeostasis