InnateDB Protein
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IDBP-93965.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ID3
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Protein Name
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inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
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Synonyms
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bHLHb25; HEIR-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363689
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InnateDB Gene
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IDBG-93963 (ID3)
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Protein Structure
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Function |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269PubMed:8437843}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q02535
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PhosphoSite |
PhosphoSite-Q02535
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3399
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UniGene |
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RefSeq |
NP_002158
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HUGO |
HGNC:5362
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OMIM |
600277
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CCDS |
CCDS237
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HPRD |
02608
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IMGT |
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EMBL |
AK290003
AL021154
BC003107
BT006791
CH471134
X66924
X69111
X73428
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GenPept |
AAH03107
AAP35437
BAF82692
CAA15950
CAA47360
CAA48862
CAA51827
EAW95060
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