Homo sapiens Protein: GALE | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-94026.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GALE | ||||||||||||||||||
Protein Name | UDP-galactose-4-epimerase | ||||||||||||||||||
Synonyms | SDR1E1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000363621 | ||||||||||||||||||
InnateDB Gene | IDBG-94020 (GALE) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. | ||||||||||||||||||
Subcellular Localization | |||||||||||||||||||
Disease Associations | Epimerase-deficiency galactosemia (EDG) [MIM:230350]: Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development. {ECO:0000269PubMed:11903335, ECO:0000269PubMed:16301867, ECO:0000269PubMed:9326324, ECO:0000269PubMed:9538513, ECO:0000269PubMed:9973283}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001509
NAD-dependent epimerase/dehydratase, N-terminal domain IPR002198 Short-chain dehydrogenase/reductase SDR IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase IPR003869 Polysaccharide biosynthesis protein, CapD-like domain IPR005886 UDP-glucose 4-epimerase GalE IPR005913 dTDP-4-dehydrorhamnose reductase IPR008089 Nucleotide sugar epimerase IPR013120 Male sterility, NAD-binding IPR013968 Polyketide synthase, KR |
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PFAM |
PF01370
PF00106 PF01073 PF02719 PF04321 PF07993 PF08659 |
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PRINTS |
PR00080
PR01713 |
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PIRSF |
PIRSF000126
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SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q14376 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q14376 | ||||||||||||||||||
TrEMBL | Q5QPP3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 2582 | ||||||||||||||||||
UniGene | Hs.713486 | ||||||||||||||||||
RefSeq | NP_000394 | ||||||||||||||||||
HUGO | HGNC:4116 | ||||||||||||||||||
OMIM | 606953 | ||||||||||||||||||
CCDS | CCDS242 | ||||||||||||||||||
HPRD | 06092 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF022382 AK314397 AL031295 BC001273 BC050685 DQ233667 DQ233668 L41668 | ||||||||||||||||||
GenPept | AAB86498 AAC39645 AAH01273 AAH50685 ABB04109 ABB04110 BAG37021 CAB40159 | ||||||||||||||||||