InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNR2

Summary

InnateDB Protein

IDBP-94063.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNR2

Protein Name

cannabinoid receptor 2 (macrophage)

Synonyms

CB-2; CB2; CX5;

Species

Homo sapiens

Ensembl Protein

ENSP00000363596

InnateDB Gene

IDBG-94061 (CNR2)

Protein Structure

UniProt Annotation

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269PubMed:10051546, ECO:0000269PubMed:12663043, ECO:0000269PubMed:12711605, ECO:0000269PubMed:18692962}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. {ECO:0000269PubMed:12153574, ECO:0000269PubMed:12511587, ECO:0000269PubMed:14657172, ECO:0000269PubMed:15266552, ECO:0000269PubMed:18692962, ECO:0000269PubMed:19496827, ECO:0000269PubMed:7556170}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity

Biological Process

GO:0001975	response to amphetamine
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0019233	sensory perception of pain
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0033004	negative regulation of mast cell activation
GO:0045759	negative regulation of action potential
GO:0050728	negative regulation of inflammatory response
GO:0051001	negative regulation of nitric-oxide synthase activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001551 Cannabinoid receptor type 2
IPR002230 Cannabinoid receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00523
PR00362

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34972