InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PNRC2

Summary

InnateDB Protein

IDBP-94068.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNRC2

Protein Name

proline-rich nuclear receptor coactivator 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363592

InnateDB Gene

IDBG-94064 (PNRC2)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. {ECO:0000269PubMed:11574675, ECO:0000269PubMed:19150429}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19150429}. Cytoplasm, P-body {ECO:0000269PubMed:19150429}.

Disease Associations

Tissue Specificity

Expressed in heart, lung, muscle and brain. {ECO:0000269PubMed:11574675}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA