Version 5.4
Homo sapiens Protein: IL22RA1
Summary
InnateDB Protein IDBP-94156.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL22RA1
Protein Name interleukin 22 receptor, alpha 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000270800
InnateDB Gene IDBG-94154 (IL22RA1)
Protein Structure
UniProt Annotation
Function Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269PubMed:11035029, ECO:0000269PubMed:11564763, ECO:0000269PubMed:11706020, ECO:0000269PubMed:12351624, ECO:0000269PubMed:12941841, ECO:0000269PubMed:17204547}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. {ECO:0000269PubMed:12407026, ECO:0000269PubMed:15308104, ECO:0000269PubMed:17828272, ECO:0000269PubMed:17900301, ECO:0000269PubMed:18061474}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004904 interferon receptor activity
GO:0005515 protein binding
GO:0042015 interleukin-20 binding
Biological Process
GO:0008150 biological_process
GO:0019221 cytokine-mediated signaling pathway
GO:0050829 defense response to Gram-negative bacterium
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR015373 Interferon alpha/beta receptor, beta chain
PFAM PF00041
PF01108
PF09294
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6P7
PhosphoSite PhosphoSite-Q8N6P7
TrEMBL
UniProt Splice Variant
Entrez Gene 58985
UniGene Hs.110915
RefSeq NP_067081
HUGO HGNC:13700
OMIM 605457
CCDS CCDS247
HPRD 16108
IMGT
EMBL AF286095 AK292204 AK313971 AL590683 AL591178 BC029273 CH471134
GenPept AAG22073 AAH29273 BAF84893 BAG36686 CAH70116 CAH72088 EAW95111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca