InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RRAGD

Summary

InnateDB Protein

IDBP-94310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRAGD

Protein Name

Ras-related GTP binding D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358423

InnateDB Gene

IDBG-94308 (RRAGD)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269PubMed:20381137}.

Subcellular Localization

Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

InterPro

IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR019009 Signal recognition particle receptor, beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00025
PF04670
PF09439

PRINTS

PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NQL2