InnateDB Protein
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IDBP-94312.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RRAGD
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Protein Name
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Ras-related GTP binding D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352131
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InnateDB Gene
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IDBG-94308 (RRAGD)
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Protein Structure
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Function |
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269PubMed:20381137}.
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Subcellular Localization |
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006762
Gtr1/RagA G protein
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF04670
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NQL2
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PhosphoSite |
PhosphoSite-Q9NQL2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58528
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UniGene |
Hs.595624
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RefSeq |
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HUGO |
HGNC:19903
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OMIM |
608268
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CCDS |
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HPRD |
12199
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IMGT |
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EMBL |
AF272036
AK289799
AL137502
AL138717
BC003088
CH471051
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GenPept |
AAG32663
AAH03088
BAF82488
CAB70775
CAB99361
CAB99362
EAW48554
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