Version 5.4
Homo sapiens Protein: ANKRD6
Summary
InnateDB Protein IDBP-94317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRD6
Protein Name ankyrin repeat domain 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000345767
InnateDB Gene IDBG-94313 (ANKRD6)
Protein Structure
UniProt Annotation
Function Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0046330 positive regulation of JNK cascade
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2G4
PhosphoSite PhosphoSite-Q9Y2G4
TrEMBL E5RJR9
UniProt Splice Variant
Entrez Gene 22881
UniGene Hs.692978
RefSeq NP_001229738
HUGO HGNC:17280
OMIM 610583
CCDS CCDS56441
HPRD 09798
IMGT
EMBL AB023174 AK096867 AL096678 AL117504 AL136971 AL138717 AL159174 BC042173
GenPept AAH42173 BAA76801 BAG53385 CAB55968 CAI42280 CAI42281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca