InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDN1

Summary

InnateDB Protein

IDBP-94326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDN1

Protein Name

MDN1, midasin homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358400

InnateDB Gene

IDBG-94324 (MDN1)

Protein Structure

UniProt Annotation

Function

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000269PubMed:22002106}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006461	protein complex assembly

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR003593 AAA+ ATPase domain
IPR011703 ATPase, AAA-3
IPR011704 ATPase, dynein-related, AAA domain
IPR012099 Midasin
IPR016024 Armadillo-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00092
PF07726
PF07728

PRINTS

PIRSF

PIRSF010340

SMART

SM00327
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt