Version 5.4
Homo sapiens Protein: MANEA
Summary
InnateDB Protein IDBP-94435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MANEA
Protein Name mannosidase, endo-alpha
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351669
InnateDB Gene IDBG-94433 (MANEA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:15677381, ECO:0000269PubMed:15760709}; Single-pass type II membrane protein {ECO:0000269PubMed:15677381, ECO:0000269PubMed:15760709}.
Disease Associations
Tissue Specificity Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain. {ECO:0000269PubMed:15677381}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004559 alpha-mannosidase activity
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017853 Glycoside hydrolase, superfamily
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SRI9
PhosphoSite PhosphoSite-Q5SRI9
TrEMBL
UniProt Splice Variant
Entrez Gene 79694
UniGene Hs.743412
RefSeq NP_078917
HUGO HGNC:21072
OMIM 612327
CCDS CCDS5032
HPRD 14357
IMGT
EMBL AJ577574 AK022900 AK291940 AL671884 AY048774 AY372528 BC137014 BC137016 BC146671 BC150199 BX537398 BX640869
GenPept AAI37015 AAI37017 AAI46672 AAI50200 AAL07306 AAQ75077 BAB14298 BAF84629 CAD97640 CAE12165 CAE45927 CAI17346 CAI17347

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca