InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UFL1

Summary

InnateDB Protein

IDBP-94454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UFL1

Protein Name

UFM1-specific ligase 1

Synonyms

KIAA0776; Maxer; NLBP; RCAD;

Species

Homo sapiens

Ensembl Protein

ENSP00000358283

InnateDB Gene

IDBG-94450 (UFL1)

Protein Structure

UniProt Annotation

Function

E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3. {ECO:0000269PubMed:20018847, ECO:0000269PubMed:20164180}.

Subcellular Localization

Endoplasmic reticulum. Cytoplasm. Note=In cytoplasm colocalizes with CDK5RAP3.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such Hep-G2, Hep 3B2.1-7, HLE and PLC. {ECO:0000269PubMed:20018847}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0071568	UFM1 conjugating enzyme activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0031397	negative regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0071569	protein ufmylation