InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNKSR1

Summary

InnateDB Protein

IDBP-94503.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNKSR1

Protein Name

connector enhancer of kinase suppressor of Ras 1

Synonyms

CNK; CNK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363371

InnateDB Gene

IDBG-94499 (CNKSR1)

Protein Structure

UniProt Annotation

Function

May function as an adapter protein or regulator of Ras signaling pathways.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0030674	protein binding, bridging

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007266	Rho protein signal transduction
GO:0016310	phosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex

Protein Structure and Domains

PDB ID

InterPro

IPR001478 PDZ domain
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR013761 Sterile alpha motif/pointed domain
IPR019555 CRIC domain, Chordata
IPR021129 Sterile alpha motif, type 1

PFAM

PF00595
PF13180
PF00169
PF10534
PF00536

PRINTS

PIRSF

SMART

SM00228
SM00454
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q969H4