InnateDB Protein
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IDBP-94508.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MMS22L
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Protein Name
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MMS22-like, DNA repair protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000275053
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InnateDB Gene
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IDBG-94504 (MMS22L)
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Protein Structure
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Function |
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. {ECO:0000269PubMed:21055983, ECO:0000269PubMed:21055984, ECO:0000269PubMed:21055985}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21055983, ECO:0000269PubMed:21055984}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000724
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double-strand break repair via homologous recombination
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GO:0031297
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replication fork processing
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZRQ5
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PhosphoSite |
PhosphoSite-Q6ZRQ5
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TrEMBL |
H9KVD8
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UniProt Splice Variant |
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Entrez Gene |
253714
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UniGene |
Hs.641979
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RefSeq |
NP_940870
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HUGO |
HGNC:21475
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OMIM |
615614
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CCDS |
CCDS5039
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HPRD |
12865
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IMGT |
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EMBL |
AK128060
AL023656
AL353679
AL590484
CH471051
CR749603
CR749822
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GenPept |
BAC87254
CAH18398
CAH18682
CAI16668
CAI20426
EAW48494
EAW48496
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