InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPX2

Summary

InnateDB Protein

IDBP-9458.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPX2

Protein Name

glutathione peroxidase 2 (gastrointestinal)

Synonyms

GI-GPx; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI;

Species

Homo sapiens

Ensembl Protein

ENSP00000374265

InnateDB Gene

IDBG-9454 (GPX2)

Protein Structure

UniProt Annotation

Function

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Subcellular Localization

Cytoplasm. Note=Mainly cytoplasmic.

Disease Associations

Tissue Specificity

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004602	glutathione peroxidase activity
GO:0009055	electron carrier activity

Biological Process

GO:0001659	temperature homeostasis
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0006979	response to oxidative stress
GO:0009609	response to symbiotic bacterium
GO:0051702	interaction with symbiont
GO:0055114	oxidation-reduction process