Version 5.4
Homo sapiens Protein: MCHR2
Summary
InnateDB Protein IDBP-94641.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCHR2
Protein Name melanin-concentrating hormone receptor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358214
InnateDB Gene IDBG-94637 (MCHR2)
Protein Structure
UniProt Annotation
Function Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR008361 Melanin-concentrating hormone receptor
IPR008362 Melanin-concentrating hormone 2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
PFAM PF00001
PF10320
PF10323
PRINTS PR00237
PR01783
PR01784
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969V1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 84539
UniGene
RefSeq NP_115892
HUGO HGNC:20867
OMIM 606111
CCDS CCDS5044
HPRD 12088
IMGT
EMBL AB058849 AB060151 AF347063 AF399937 AK123634 AL590725 AY029596 AY562946 BC095515 CH471051
GenPept AAH95515 AAK32193 AAK38157 AAL05528 AAS72374 BAB55677 BAB87842 BAG53926 CAH70022 EAW48460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca