InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFN

Summary

InnateDB Protein

IDBP-94740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFN

Protein Name

stratifin

Synonyms

YWHAS;

Species

Homo sapiens

Ensembl Protein

ENSP00000340989

InnateDB Gene

IDBG-94738 (SFN)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269PubMed:18382127}.p53-regulated inhibitor of G2/M progression. {ECO:0000269PubMed:18382127}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.

Disease Associations

Tissue Specificity

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 205 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	205 [view]
Protein-Protein	203 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001836	release of cytochrome c from mitochondria
GO:0003334	keratinocyte development
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010482	regulation of epidermal cell division
GO:0010839	negative regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030307	positive regulation of cell growth
GO:0031424	keratinization
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588	skin development
GO:0045606	positive regulation of epidermal cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0051726	regulation of cell cycle
GO:0061024	membrane organization
GO:0061436	establishment of skin barrier
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030659	cytoplasmic vesicle membrane
GO:0070062	extracellular vesicular exosome