InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR0B2

Summary

InnateDB Protein

IDBP-94764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR0B2

Protein Name

nuclear receptor subfamily 0, group B, member 2

Synonyms

SHP; SHP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000254227

InnateDB Gene

IDBG-94762 (NR0B2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. {ECO:0000269PubMed:14752053}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14752053}. Cytoplasm {ECO:0000269PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:11136233}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Liver. Low levels of expression were detected in heart and pancreas. {ECO:0000269PubMed:8650544}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	78 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046965	retinoid X receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0008203	cholesterol metabolic process
GO:0009749	response to glucose
GO:0010467	gene expression
GO:0030521	androgen receptor signaling pathway
GO:0031100	organ regeneration
GO:0032024	positive regulation of insulin secretion
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated