Version 5.4
Homo sapiens Protein: QRSL1
Summary
InnateDB Protein IDBP-94901.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QRSL1
Protein Name glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358042
InnateDB Gene IDBG-94899 (QRSL1)
Protein Structure
UniProt Annotation
Function Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255HAMAP-Rule:MF_03150, ECO:0000269PubMed:19805282}.
Subcellular Localization Mitochondrion {ECO:0000255HAMAP- Rule:MF_03150, ECO:0000269PubMed:19805282}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation
Cellular Component
GO:0005739 mitochondrion
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR000120 Amidase
IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit
IPR023631 Amidase signature domain
PFAM PF01425
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0R6
PhosphoSite PhosphoSite-Q9H0R6
TrEMBL
UniProt Splice Variant
Entrez Gene 55278
UniGene Hs.597015
RefSeq NP_060762
HUGO HGNC:21020
OMIM
CCDS CCDS5057
HPRD 15199
IMGT
EMBL AK001851 AK022251 AK023509 AL136679 AL390074 BC006084 BC014389 CH471051
GenPept AAH06084 AAH14389 BAA91941 BAB13996 BAB14592 CAB66614 CAH72093 CAH72094 EAW48407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca