InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC63

Summary

InnateDB Protein

IDBP-94974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC63

Protein Name

SEC63 homolog (S. cerevisiae)

Synonyms

DNAJC23; ERdj2; PRO2507; SEC63L;

Species

Homo sapiens

Ensembl Protein

ENSP00000357998

InnateDB Gene

IDBG-94972 (SEC63)

Protein Structure

UniProt Annotation

Function

Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Polycystic liver disease (PCLD) [MIM:174050]: A hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts. {ECO:0000269PubMed:15133510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed, with high levels in the liver. {ECO:0000269PubMed:15133510}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001889	liver development
GO:0006612	protein targeting to membrane
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0006620	posttranslational protein targeting to membrane
GO:0006807	nitrogen compound metabolic process
GO:0010259	multicellular organismal aging
GO:0031204	posttranslational protein targeting to membrane, translocation
GO:0072001	renal system development

Cellular Component

GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane