InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTRA3

Summary

InnateDB Protein

IDBP-9505.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTRA3

Protein Name

HtrA serine peptidase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303766

InnateDB Gene

IDBG-9503 (HTRA3)

Protein Structure

UniProt Annotation

Function

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:21321049}. Note=Secretion increased during decidualization of endometrial stromal cells.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. {ECO:0000269PubMed:12513693, ECO:0000269PubMed:16650464, ECO:0000269PubMed:21321049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0001558	regulation of cell growth
GO:0006508	proteolysis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR001254 Peptidase S1
IPR001478 PDZ domain
IPR001940 Peptidase S1C
IPR002350 Kazal domain
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00219
PF00089
PF00595
PF13180
PF00050
PF07648

PRINTS

PR00834

PIRSF

SMART

SM00121
SM00020
SM00228
SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt