Version 5.4
Homo sapiens Protein: SESN1
Summary
InnateDB Protein IDBP-95050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SESN1
Protein Name sestrin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349061
InnateDB Gene IDBG-95048 (SESN1)
Protein Structure
UniProt Annotation
Function Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. {ECO:0000269PubMed:15105503}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12607115}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:1901031 regulation of response to reactive oxygen species
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006730 Sestrin
IPR029032 AhpD-like
PFAM PF04636
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6P5
PhosphoSite PhosphoSite-Q9Y6P5
TrEMBL
UniProt Splice Variant
Entrez Gene 27244
UniGene Hs.600713
RefSeq NP_001186862
HUGO HGNC:21595
OMIM 606103
CCDS CCDS56445
HPRD 07310
IMGT
EMBL AF033120 AF033121 AF033122 AK001886 AL390208 BC112036 BC113569 CH471051
GenPept AAD04810 AAD04811 AAD04812 AAI12037 AAI13570 BAA91961 CAI16720 EAW48367 EAW48368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca