Version 5.4
Homo sapiens Protein: THEMIS2
Summary
InnateDB Protein IDBP-95064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THEMIS2
Protein Name chromosome 1 open reading frame 38
Synonyms C1orf38; ICB-1;
Species Homo sapiens
Ensembl Protein ENSP00000363031
InnateDB Gene IDBG-95058 (THEMIS2)
Protein Structure
UniProt Annotation
Function May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production. {ECO:0000269PubMed:20644716}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1. {ECO:0000269PubMed:9563507}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TEJ8
PhosphoSite PhosphoSite-Q5TEJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 9473
UniGene Hs.10649
RefSeq NP_001273044
HUGO HGNC:16839
OMIM
CCDS CCDS41290
HPRD 12728
IMGT
EMBL AB035482 AB050854 AF044895 AK303090 AK303141 AL109927 BC031655 BC132692 BC133049 CR749321
GenPept AAC16284 AAH31655 AAI32693 AAI33050 BAA96464 BAB33313 BAG64201 BAG64245 CAH18176 CAI21769 CAI21770 CAI21771 CAI21772 CAI21773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca