InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MICAL1

Summary

InnateDB Protein

IDBP-95129.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICAL1

Protein Name

microtubule associated monoxygenase, calponin and LIM domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351385

InnateDB Gene

IDBG-95123 (MICAL1)

Protein Structure

UniProt Annotation

Function

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. {ECO:0000269PubMed:18305261, ECO:0000269PubMed:21864500, ECO:0000305}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. {ECO:0000269PubMed:11827972}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0017124	SH3 domain binding
GO:0071949	FAD binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0019417	sulfur oxidation
GO:0030042	actin filament depolymerization
GO:0055114	oxidation-reduction process