Version 5.4
Homo sapiens Protein: XKR8
Summary
InnateDB Protein IDBP-95136.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XKR8
Protein Name XK, Kell blood group complex subunit-related family, member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362991
InnateDB Gene IDBG-95134 (XKR8)
Protein Structure
UniProt Annotation
Function Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis. {ECO:0000269PubMed:23845944}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:23845944}; Multi-pass membrane protein {ECO:0000269PubMed:23845944}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0043652 engulfment of apoptotic cell
GO:0070782 phosphatidylserine exposure on apoptotic cell surface
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR018629 Transport protein XK
PFAM PF09815
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6D3
PhosphoSite PhosphoSite-
TrEMBL Q9NW55
UniProt Splice Variant
Entrez Gene 55113
UniGene
RefSeq NP_060523
HUGO HGNC:25508
OMIM
CCDS CCDS315
HPRD 07661
IMGT
EMBL AK001169 AK026024 AL512288 AY534246 BC003606 BC013379 BC028564 CH471059
GenPept AAH03606 AAH13379 AAH28564 AAT07095 BAA91531 BAB15326 CAI14292 EAX07719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca