InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR6

Summary

InnateDB Protein

IDBP-95195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR6

Protein Name

G protein-coupled receptor 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000275169

InnateDB Gene

IDBG-95193 (GPR6)

Protein Structure

UniProt Annotation

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305PubMed:19059244}; Multi-pass membrane protein {ECO:0000305PubMed:19059244}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186

G-protein coupled receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000723 G protein-coupled receptor 3/6/12 orphan
IPR001151 G protein-coupled receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00644
PR00649

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46095