Version 5.4
Homo sapiens Protein: SESN2
Summary
InnateDB Protein IDBP-95200.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SESN2
Protein Name sestrin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253063
InnateDB Gene IDBG-95198 (SESN2)
Protein Structure
UniProt Annotation
Function Involved in the reduction of peroxiredoxins. {ECO:0000269PubMed:15105503}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12607115}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006635 fatty acid beta-oxidation
GO:0006914 autophagy
GO:0007005 mitochondrion organization
GO:0009749 response to glucose
GO:0032042 mitochondrial DNA metabolic process
GO:0032868 response to insulin
GO:0042593 glucose homeostasis
GO:0043491 protein kinase B signaling
GO:0046323 glucose import
GO:0070328 triglyceride homeostasis
GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis
GO:1901031 regulation of response to reactive oxygen species
GO:2000479 regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006730 Sestrin
IPR029032 AhpD-like
PFAM PF04636
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58004
PhosphoSite PhosphoSite-P58004
TrEMBL
UniProt Splice Variant
Entrez Gene 83667
UniGene Hs.625462
RefSeq NP_113647
HUGO HGNC:20746
OMIM 607767
CCDS CCDS321
HPRD 06378
IMGT
EMBL AK025640 AK027896 AK315710 AL136551 AL353622 AY123223 BC013304 BC033719 CH471059
GenPept AAH13304 AAH33719 AAM92261 BAB55438 BAG38070 CAB66486 CAI19133 EAX07703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca