Version 5.4
Homo sapiens Protein: MED18
Summary
InnateDB Protein IDBP-95203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED18
Protein Name mediator complex subunit 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362948
InnateDB Gene IDBG-95201 (MED18)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 60 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR019095 Mediator complex, subunit Med18, metazoa/fungi
PFAM PF09637
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUE0
PhosphoSite PhosphoSite-Q9BUE0
TrEMBL B4DJL3
UniProt Splice Variant
Entrez Gene 54797
UniGene Hs.479911
RefSeq NP_060108
HUGO HGNC:25944
OMIM 612384
CCDS CCDS322
HPRD 17476
IMGT
EMBL AB107222 AK000052 AK296130 AL353622 BC002694 CH471059
GenPept AAH02694 BAA90910 BAD06869 BAG58875 CAI19132 EAX07699 EAX07700 EAX07702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca