InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A16

Summary

InnateDB Protein

IDBP-95257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A16

Protein Name

solute carrier family 22 (organic cation/carnitine transporter), member 16

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357915

InnateDB Gene

IDBG-95255 (SLC22A16)

Protein Structure

UniProt Annotation

Function

High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent. {ECO:0000269PubMed:12089149, ECO:0000269PubMed:15963465}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269PubMed:12089149}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.

Disease Associations

Tissue Specificity

Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase. {ECO:0000269PubMed:12089149, ECO:0000269PubMed:12372408, ECO:0000269PubMed:12384147, ECO:0000269PubMed:15963465, ECO:0000269PubMed:17197897, ECO:0000269PubMed:17581421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005275	amine transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015226	carnitine transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0015695	organic cation transport
GO:0015837	amine transport
GO:0015879	carnitine transport
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0046717	acid secretion
GO:0055085	transmembrane transport
GO:1902603	carnitine transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86VW1

PhosphoSite