InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OPRD1

Summary

InnateDB Protein

IDBP-95303.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPRD1

Protein Name

opioid receptor, delta 1

Synonyms

OPRD;

Species

Homo sapiens

Ensembl Protein

ENSP00000234961

InnateDB Gene

IDBG-95301 (OPRD1)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269PubMed:22184124, ECO:0000269PubMed:7808419, ECO:0000269PubMed:8201839}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22184124, ECO:0000269PubMed:7808419, ECO:0000269PubMed:8201839}; Multi- pass membrane protein {ECO:0000269PubMed:22184124, ECO:0000269PubMed:7808419, ECO:0000269PubMed:8201839}.

Disease Associations

Tissue Specificity

Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. {ECO:0000269PubMed:22417668, ECO:0000269PubMed:7808419}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004985	opioid receptor activity
GO:0005515	protein binding
GO:0038046	enkephalin receptor activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0008344	adult locomotory behavior
GO:0038003	opioid receptor signaling pathway
GO:0051924	regulation of calcium ion transport
GO:0051930	regulation of sensory perception of pain
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0031982	vesicle
GO:0032590	dendrite membrane
GO:0043679	axon terminus
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000321 Delta opioid receptor
IPR000586 Somatostatin receptor family
IPR000611 Neuropeptide Y receptor family
IPR001418 Opioid receptor
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00525
PR00246
PR01012
PR00384
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P41143