Version 5.4
Homo sapiens Protein: SLC16A10
Summary
InnateDB Protein IDBP-95355.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A10
Protein Name solute carrier family 16, member 10 (aromatic amino acid transporter)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357844
InnateDB Gene IDBG-95351 (SLC16A10)
Protein Structure
UniProt Annotation
Function Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart. {ECO:0000269PubMed:11827462}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015801 aromatic amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF71
PhosphoSite PhosphoSite-Q8TF71
TrEMBL Q9P1I2
UniProt Splice Variant
Entrez Gene 117247
UniGene Hs.615125
RefSeq NP_061063
HUGO HGNC:17027
OMIM 607550
CCDS CCDS5089
HPRD 09613
IMGT
EMBL AB057445 AF116652 AK126183 AK172789 AL360227 BC017968 BC066985 CH471051
GenPept AAF71072 AAH17968 AAH66985 BAB84670 BAD18768 BAG54292 CAH73732 EAW48298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca