Version 5.4
Homo sapiens Protein: LAPTM5
Summary
InnateDB Protein IDBP-95384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAPTM5
Protein Name lysosomal protein transmembrane 5
Synonyms CLAST6;
Species Homo sapiens
Ensembl Protein ENSP00000294507
InnateDB Gene IDBG-95382 (LAPTM5)
Protein Structure
UniProt Annotation
Function May have a special functional role during embryogenesis and in adult hematopoietic cells. {ECO:0000269PubMed:8661146}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:8661146}; Multi-pass membrane protein {ECO:0000269PubMed:8661146}.
Disease Associations
Tissue Specificity Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues. Highly expressed in peripheral blood leukocytes, thymus, spleen and lung, followed by placenta, liver and kidney. {ECO:0000269PubMed:8661146}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004687 Lysosomal-associated transmembrane protein 4/5
IPR018396 Lysosomal-associated transmembrane protein, 4A/5
PFAM PF03821
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13571
PhosphoSite PhosphoSite-Q13571
TrEMBL Q5TBB8
UniProt Splice Variant
Entrez Gene 7805
UniGene Hs.619076
RefSeq NP_006753
HUGO HGNC:29612
OMIM 601476
CCDS CCDS337
HPRD 03280
IMGT
EMBL AK292009 BC106896 BC106897 CH471059 D42042 U30498 U51240
GenPept AAA74018 AAB08975 AAI06897 AAI06898 BAA07643 BAF84698 EAX07640 EAX07641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca