InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HCRTR1

Summary

InnateDB Protein

IDBP-95460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCRTR1

Protein Name

hypocretin (orexin) receptor 1

Synonyms

OX1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000362810

InnateDB Gene

IDBG-95458 (HCRTR1)

Protein Structure

UniProt Annotation

Function

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016499	orexin receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000204 Orexin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR004059 Orexin receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR01064
PR00237
PR01012
PR01521

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43613