Version 5.4
Homo sapiens Protein: PEF1
Summary
InnateDB Protein IDBP-95480.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEF1
Protein Name penta-EF-hand domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362807
InnateDB Gene IDBG-95478 (PEF1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11278427}. Membrane {ECO:0000269PubMed:11278427}; Peripheral membrane protein {ECO:0000269PubMed:11278427}. Note=Membrane-associated in the presence of Ca(2+).
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006508 proteolysis
GO:0051592 response to calcium ion
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBV8
PhosphoSite PhosphoSite-Q9UBV8
TrEMBL
UniProt Splice Variant
Entrez Gene 553115
UniGene Hs.470417
RefSeq NP_036524
HUGO HGNC:30009
OMIM 610033
CCDS CCDS345
HPRD 10143
IMGT
EMBL AB018357 AB026628 AK001420 AY359011 BC002773 BC012561 CR542139
GenPept AAH02773 AAH12561 AAQ89370 BAA84922 BAA85163 BAA91680 CAG46936

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca