InnateDB Protein
|
IDBP-95637.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
EIF3I
|
Protein Name
|
eukaryotic translation initiation factor 3, subunit I
|
Synonyms
|
eIF3-beta; eIF3-p36; EIF3S2; PRO2242; TRIP-1; TRIP1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000362688
|
InnateDB Gene
|
IDBG-95635 (EIF3I)
|
Protein Structure
|
|
Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|
Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03008}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
103
[view]
|
Protein-Protein |
99
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
|
PFAM |
PF00400
|
PRINTS |
|
PIRSF |
|
SMART |
SM00320
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q13347
|
PhosphoSite |
PhosphoSite-Q13347
|
TrEMBL |
Q9P1D9
|
UniProt Splice Variant |
|
Entrez Gene |
8668
|
UniGene |
|
RefSeq |
NP_003748
|
HUGO |
HGNC:3272
|
OMIM |
603911
|
CCDS |
CCDS357
|
HPRD |
04884
|
IMGT |
|
EMBL |
AF116697
AK289356
AK289882
AL049795
AL121991
BC000413
BC003140
BT019597
CH471059
U36764
U39067
|
GenPept |
AAC50224
AAC97144
AAF71117
AAH00413
AAH03140
AAV38404
BAF82045
BAF82571
EAX07553
|
|
|