InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ROS1

Summary

InnateDB Protein

IDBP-95787.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROS1

Protein Name

c-ros oncogene 1 , receptor tyrosine kinase

Synonyms

c-ros-1; MCF3; ROS;

Species

Homo sapiens

Ensembl Protein

ENSP00000357494

InnateDB Gene

IDBG-95785 (ROS1)

Protein Structure

UniProt Annotation

Function

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269PubMed:11094073, ECO:0000269PubMed:16885344}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells. {ECO:0000269PubMed:12661006}.

Tissue Specificity

Expressed in brain. Expression is increased in primary gliomas. {ECO:0000269PubMed:8143271}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0002066	columnar/cuboidal epithelial cell development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0010966	regulation of phosphate transport
GO:0016049	cell growth
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0032006	regulation of TOR signaling
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00058
PF00069
PF07714
PF00041
PF01108

PRINTS

PR00109

PIRSF

SMART

SM00135
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt