InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUS1

Summary

InnateDB Protein

IDBP-95854.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUS1

Protein Name

nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357480

InnateDB Gene

IDBG-95852 (NUS1)

Protein Structure

UniProt Annotation

Function

Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.Essential component of the dolichol monophosphate (Dol- P) biosynthetic machinery.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:19723497, ECO:0000269PubMed:21572394}; Single-pass type I membrane protein {ECO:0000269PubMed:19723497, ECO:0000269PubMed:21572394}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups

Biological Process

GO:0001525	angiogenesis
GO:0006486	protein glycosylation
GO:0030154	cell differentiation
GO:0032367	intracellular cholesterol transport
GO:0055092	sterol homeostasis