InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN1A1

Summary

InnateDB Protein

IDBP-95961.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN1A1

Protein Name

mannosidase, alpha, class 1A, member 1

Synonyms

HUMM3; HUMM9; MAN9;

Species

Homo sapiens

Ensembl Protein

ENSP00000357453

InnateDB Gene

IDBG-95959 (MAN1A1)

Protein Structure

UniProt Annotation

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding
GO:0015923	mannosidase activity

Biological Process

GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome