Version 5.4
Homo sapiens Protein: SERINC1
Summary
InnateDB Protein IDBP-95998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERINC1
Protein Name serine incorporator 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342962
InnateDB Gene IDBG-95996 (SERINC1)
Protein Structure
UniProt Annotation
Function Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015194 L-serine transmembrane transporter activity
Biological Process
GO:0006658 phosphatidylserine metabolic process
GO:0006665 sphingolipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0015825 L-serine transport
GO:0051347 positive regulation of transferase activity
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005016 Serine incorporator/TMS membrane protein
PFAM PF03348
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRX5
PhosphoSite PhosphoSite-Q9NRX5
TrEMBL
UniProt Splice Variant
Entrez Gene 57515
UniGene Hs.146668
RefSeq NP_065806
HUGO HGNC:13464
OMIM 614548
CCDS CCDS5125
HPRD 15480
IMGT
EMBL AB033079 AF087902 AF092436 AF164794 AK128781 AL137261 AY358429 BC028607 BC033029 CH471051 Z99129
GenPept AAF80758 AAH28607 AAH33029 AAP97200 AAP97211 AAQ88795 BAA86567 BAG54731 CAB70662 CAD92585 EAW48172 EAW48173

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca