Version 5.4
Homo sapiens Protein: NCOA7
Summary
InnateDB Protein IDBP-96132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA7
Protein Name nuclear receptor coactivator 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357341
InnateDB Gene IDBG-96130 (NCOA7)
Protein Structure
UniProt Annotation
Function Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269PubMed:11971969}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line. {ECO:0000269PubMed:11971969}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257 nuclear hormone receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004182 GRAM domain
IPR006571 TLDc domain
IPR018392 LysM domain
PFAM PF02893
PF07534
PF01476
PRINTS
PIRSF
SMART SM00568
SM00584
SM00257
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NI08
PhosphoSite PhosphoSite-Q8NI08
TrEMBL Q8N3C8
UniProt Splice Variant
Entrez Gene 135112
UniGene Hs.739369
RefSeq NP_001186549
HUGO HGNC:21081
OMIM 609752
CCDS CCDS5132
HPRD 14814
IMGT
EMBL AB074157 AF493978 AK094706 AK294558 AL035689 AL078594 AL136163 AL832628 AL834442 AY364254 BC036461 BC071782 BC137094 BC137095 BX537385 CH471051
GenPept AAH36461 AAH71782 AAI37095 AAI37096 AAM27392 AAQ76813 BAC04402 BAE45732 BAH11810 CAD39102 CAD89948 CAD97627 CAI20072 CAI42386 CAI42397 EAW48133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca