Version 5.4
Homo sapiens Protein: HINT3
Summary
InnateDB Protein IDBP-96150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HINT3
Protein Name histidine triad nucleotide binding protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000229633
InnateDB Gene IDBG-96148 (HINT3)
Protein Structure
UniProt Annotation
Function Hydrolyzes phosphoramidate and acyl-adenylate substrates. {ECO:0000269PubMed:17870088}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17870088}. Nucleus {ECO:0000269PubMed:17870088}. Note=Localized as aggregates in the cytoplasm and the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001310 Histidine triad (HIT) protein
IPR011146 HIT-like domain
PFAM PF01230
PRINTS PR00332
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQE9
PhosphoSite PhosphoSite-Q9NQE9
TrEMBL
UniProt Splice Variant
Entrez Gene 135114
UniGene Hs.72325
RefSeq NP_612638
HUGO HGNC:18468
OMIM 609998
CCDS CCDS5133
HPRD 17107
IMGT
EMBL AK057688 AL035689 AY035387 AY035388 AY486460 AY486461 BC015732 CH471051
GenPept AAH15732 AAK71347 AAK71348 AAR89533 AAR89534 BAG51953 CAB92728 EAW48129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca