InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPW

Summary

InnateDB Protein

IDBP-96162.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPW

Protein Name

centromere protein W

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357311

InnateDB Gene

IDBG-96160 (CENPW)

Protein Structure

UniProt Annotation

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269PubMed:19070575, ECO:0000269PubMed:19533040, ECO:0000269PubMed:21695110, ECO:0000269PubMed:22002061, ECO:0000269PubMed:22304917}.

Subcellular Localization

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.

Disease Associations

Tissue Specificity

Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269PubMed:17079448, ECO:0000269PubMed:17610844}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0034080	centromere-specific nucleosome assembly
GO:0051276	chromosome organization
GO:0051382	kinetochore assembly