InnateDB Protein
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IDBP-96169.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RSPO3
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Protein Name
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R-spondin 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349131
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InnateDB Gene
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IDBG-96167 (RSPO3)
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Protein Structure
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Function |
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076, ECO:0000269PubMed:22615920}.
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Subcellular Localization |
Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269PubMed:12463421}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0060070
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canonical Wnt signaling pathway
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GO:0060670
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branching involved in labyrinthine layer morphogenesis
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Cellular Component |
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PDB ID |
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InterPro |
IPR000884
Thrombospondin, type 1 repeat
IPR006212
Furin-like repeat
IPR009030
Insulin-like growth factor binding protein, N-terminal
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PFAM |
PF00090
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PRINTS |
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PIRSF |
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SMART |
SM00209
SM00261
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BXY4
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PhosphoSite |
PhosphoSite-Q9BXY4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84870
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UniGene |
Hs.135254
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RefSeq |
NP_116173
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HUGO |
HGNC:20866
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OMIM |
610574
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CCDS |
CCDS5135
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HPRD |
18181
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IMGT |
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EMBL |
AF251057
AK027346
AK314912
AL031776
AL590733
BC022367
CH471051
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GenPept |
AAH22367
AAK34947
BAB55051
BAG37424
CAH71124
CAH71125
CAI20141
CAI20142
EAW48115
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