Version 5.4
Homo sapiens Protein: ADPRHL2
Summary
InnateDB Protein IDBP-96297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADPRHL2
Protein Name ADP-ribosylhydrolase like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362273
InnateDB Gene IDBG-96295 (ADPRHL2)
Protein Structure
UniProt Annotation
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269PubMed:16278211}.
Subcellular Localization Cytoplasm. Mitochondrion matrix. Nucleus.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:16278211}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR005502 ADP-ribosylation/Crystallin J1
PFAM PF03747
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NX46
PhosphoSite PhosphoSite-Q9NX46
TrEMBL B7ZAN4
UniProt Splice Variant
Entrez Gene 54936
UniGene Hs.18021
RefSeq NP_060295
HUGO HGNC:21304
OMIM 610624
CCDS CCDS402
HPRD 12432
IMGT
EMBL AF212236 AJ313333 AJ427295 AK000453 AK223037 AK295283 AK316349 AL138787 BC014169 CH471059 CR457237
GenPept AAH14169 AAK14922 BAA91174 BAD96757 BAG58267 BAH14720 CAC21453 CAC85940 CAD20316 CAG33518 EAX07389

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca