InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK40

Summary

InnateDB Protein

IDBP-96353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK40

Protein Name

serine/threonine kinase 40

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362222

InnateDB Gene

IDBG-96349 (STK40)

Protein Structure

UniProt Annotation

Function

May be a negative regulator of NF-kappa-B and p53- mediated gene transcription. {ECO:0000269PubMed:13679039}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:13679039}. Cytoplasm {ECO:0000269PubMed:13679039}.

Disease Associations

Tissue Specificity

Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:13679039}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0003016	respiratory system process
GO:0005977	glycogen metabolic process
GO:0006468	protein phosphorylation
GO:0010468	regulation of gene expression
GO:0030324	lung development
GO:0035264	multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0043408	regulation of MAPK cascade
GO:0048286	lung alveolus development
GO:0060425	lung morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt