InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LSM10

Summary

InnateDB Protein

IDBP-96360.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LSM10

Protein Name

LSM10, U7 small nuclear RNA associated

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319341

InnateDB Gene

IDBG-96358 (LSM10)

Protein Structure

UniProt Annotation

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. {ECO:0000269PubMed:16914750}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11574479}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0071208	histone pre-mRNA DCP binding

Biological Process

GO:0000084	mitotic S phase
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0008334	histone mRNA metabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing