Version 5.4
Homo sapiens Protein: ARHGAP18
Summary
InnateDB Protein IDBP-96399.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP18
Protein Name Rho GTPase activating protein 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357131
InnateDB Gene IDBG-96397 (ARHGAP18)
Protein Structure
UniProt Annotation
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250UniProtKB:Q9BRR9}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PRINTS
PIRSF
SMART SM00324
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N392
PhosphoSite PhosphoSite-Q8N392
TrEMBL
UniProt Splice Variant
Entrez Gene 93663
UniGene Hs.486458
RefSeq NP_277050
HUGO HGNC:21035
OMIM 613351
CCDS CCDS34535
HPRD 12474
IMGT
EMBL AB053293 AL450310 AL834511 BC017223 BC039611 BC062417 BC101708 BC107416 BC111940 CH471051
GenPept AAH17223 AAH39611 AAH62417 AAI01709 AAI07417 AAI11941 BAB61887 CAD39167 CAH72298 EAW48076 EAW48077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca