InnateDB Protein
|
IDBP-96404.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ZC3H12A
|
Protein Name
|
zinc finger CCCH-type containing 12A
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000362179
|
InnateDB Gene
|
IDBG-96402 (ZC3H12A)
|
Protein Structure
|
|
Function |
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. {ECO:0000250, ECO:0000269PubMed:16574901, ECO:0000269PubMed:18364357, ECO:0000269PubMed:22561375}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:16574901}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
23
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0001525
|
angiogenesis
|
GO:0006915
|
apoptotic process
|
GO:0010508
|
positive regulation of autophagy
|
GO:0010628
|
positive regulation of gene expression
|
GO:0010629
|
negative regulation of gene expression
|
GO:0010884
|
positive regulation of lipid storage
|
GO:0030154
|
cell differentiation
|
GO:0032088
|
negative regulation of NF-kappaB transcription factor activity
|
GO:0032715
|
negative regulation of interleukin-6 production
|
GO:0032720
|
negative regulation of tumor necrosis factor production
|
GO:0043031
|
negative regulation of macrophage activation
|
GO:0045019
|
negative regulation of nitric oxide biosynthetic process
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0045600
|
positive regulation of fat cell differentiation
|
GO:0071222
|
cellular response to lipopolysaccharide
|
GO:0090305
|
nucleic acid phosphodiester bond hydrolysis
|
GO:2000379
|
positive regulation of reactive oxygen species metabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR021869
Ribonuclease Zc3h12a-like
|
PFAM |
PF11977
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5D1E8
|
PhosphoSite |
PhosphoSite-Q5D1E8
|
TrEMBL |
C0LED9
|
UniProt Splice Variant |
|
Entrez Gene |
80149
|
UniGene |
Hs.656294
|
RefSeq |
NP_079355
|
HUGO |
HGNC:26259
|
OMIM |
610562
|
CCDS |
CCDS417
|
HPRD |
08021
|
IMGT |
|
EMBL |
AK026884
AL034379
AL449284
AY920403
BC005001
CH471059
CR457364
FJ695517
|
GenPept |
AAH05001
AAX14017
ACN39723
BAB15581
CAG33645
CAH73689
CAI20551
EAX07346
EAX07347
|
|
|